The Ion endoluminal system is a new robotic platform for minimally invasive biopsy deep in the peripheral lung. The system features an ultra-thin, human-controlled robotic catheter that allows physicians to navigate into hard-to-reach airways with unprecedented stability and precision. Ion offers capabilities that are unique and powerful: Reach. We invented a flexible robotic catheter that is small enough to reach the airways in all 18 segments of the lung, and precise and stable enough to navigate the tortuous path to get there. Our incredibly thin and flexible vision probe provides direct visualization the entire way. Precision. In many cases, the physician must be able to see beyond the walls of the lung to target the lesion. To solve this, we integrated an innovative fiber-optic shape sensor that provides precise location and shape information throughout the whole navigation and biopsy process. Unlike other tracking technologies, our fiber optic shape sensor is not sensitive to metal objects. The information provided by our shape sensor is coupled with 3D planning software that helps physicians map a detailed virtual plan of their patient’s lung. Targeting and biopsy are performed via these enhanced digital tools. Stability. Finally, we developed the Flexision needle—a flexible biopsy needle that slides through the twists, turns, and bends of the catheter smoothly without affecting aim. All of these technologies work together and strive to overcome the challenges of seeking a tissue diagnosis in the peripheral lung.